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In addition, RT also impacts redox metabolism in cancer via the formation of reactive oxygen species leading to radiation-induced oxidative stress 20

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Myo-cardiomyopathy is commonly associated with the A8344G MERRF mutation

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While further studies are clearly needed to define the specific mechanisms underlying the ability of substance P to augment CNS inflammation and its role in pathogen clearance, the available data raise the intriguing possibility that currently approved NK-1R antagonists, such as aprepitant, could be repurposed for use as a co-therapy to limit neuroinflammatory damage associated with infectious agents and certain neurodegenerative conditions